Program

9:00-9:05Opening Remarks

Toshikazu Ushijima (Hoshi University)

9:05-9:10Welcome Address

Masanori Hatakeyama (Institute of Microbial Chemistry)

9:10-10:05Session 1: Alterations of Epigenomic Regulators in Cancer

Bin Tean Teh (National Cancer Centre Singapore)

New Insights on Functions of Clear Cell Renal Cell Carcinoma Related Genes: VHL, PBRM1, and BAP1

Keisuke Kataoka (Keio University)

Pan-cancer integrative analyses reveal functional cooperativity among epigenetic driver mutations

10:20-11:50ASPIRE Special Session

Shinichi Yachida (The University of Osaka)

Early-Life Exposure to Colibactin-Producing Bacteria Shapes the Mutational Landscape of Japanese Colorectal Cancer

Mathieu Lupien (University of Toronto)

Epigenetic Determinants of Tumour-Initiating Properties

Faiyaz Notta (University of Toronto)

The Subclonal Footprint of Early Dissemination in Pancreatic Cancer

12:10-12:55Luncheon Seminar sponsored by OHARA Pharmaceutical Co., Ltd.

Takeshi Inukai (University of Yamanashi)

Epigenetic modification resembling gene imprinting represents unique genetic background for anti-tumor activity of l-asparaginase

13:10-14:35Session 2: Frontiers of Epigenetic Therapy in Solid Tumors

Hiromu Suzuki (Sapporo Medical University)

DOT1L inhibition exerts anti-tumor effects by activating interferon signaling in cancer cells

Alfred Cheng (The Chinese University of Hong Kong)

Enhancing immunotherapy via epigenetic modulation of lipid metabolic vulnerability

Wei-Guo Zhu (Shenzhen University Medical School)

The initial dynamic changes of chromatin upon DNA damage

14:35-15:25Session 3: Epigenomic Drug Discovery Using Novel Modalities

Yutaka Kondo (Nagoya University)

Targeting non-coding RNAs to open a new era of cancer therapy

Shigehiro Kawashima (The University of Tokyo)

Catalyst-Enabled Chemical Epigenome Editing through Regioselective Histone Acetylation for Cancer Therapy

15:50-16:35Sweets Seminar sponsored by KEYENCE CORPORATION

Kyoko Hida (Hokkaido University)

Inflammaging of endothelial cells and cancer progression

16:35-17:50Poster Session

9:00-9:55Session 4: Epigenetic Therapies Targeting the Tumor Microenvironment

Kyoko Hida (Hokkaido University)

Heterogeneity in tumor endothelial cells

Hyun-Soo Cho (Korea Research Institute of Bioscience and Biotechnology)

Microbiome-driven epigenetic modulation in cancer: Toward histone methyltransferase-targeted therapeutics

9:55-10:50Session 5: Early Cancer Diagnosis Using Epigenomic Alterations

Young-Joon Kim (Yonsei University)

DNA Methylation-Based Liquid Biopsy for Early Detection, Recurrence Prediction, and Molecular Classification of Hepatocellular Carcinoma

Toshikazu Ushijima (Hoshi University)

Epigenetic Field for Cancer Risk Diagnosis

11:05-11:49Selected Oral Presentation Session

Alaa Ahmad (Hokkaido University)

Dual Epigenetic intervention to enhance the MHC-I-dependent immune response against solid tumors

Miho Sekai (Kyoto University)

Identification of CD44v6 as a marker for precancerous lesions in pancreatic cancer

Seiichiro Ishihara (Hokkaido University)

Stiffness of extracellular matrix regulates growth of cancer cells via ATF5 activation

Yusuke Shirai (Hokkaido University)

Analysis of Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Using Hydrogels

12:10-12:55Luncheon Seminar sponsored by CyberomiX Inc.

Yuta Takahashi (Kumamoto University)

Transgenerational Inheritance of Epigenetic Memory in Mammals

13:10-14:00Session 6: Current Status and Future Perspectives in Hematologic Malignancies

Makoto Yamagishi (The University of Tokyo)

Editing the epigenome: multi-omics driven drug discovery & first-in-class therapy targeting histone methylation

Shinya Kimura (Saga University)

Toward a Cure for Chronic Myeloid Leukemia: Unraveling the Immune Microenvironment and Eradicating Leukemic Stem Cells

14:00-14:05Closing Remarks

Wei-Guo Zhu (Shenzhen University Medical School)